Saar B, Heverhagen J T, Obst T, Berthold L D, Kopp I, Klose K J, Wagner H J
Department of Radiology, University Hospital Rechts der Isar, Technische Universitaet of Munich, Germany.
Invest Radiol. 2000 Sep;35(9):521-6. doi: 10.1097/00004424-200009000-00001.
An ex vivo study and a clinical, prospective, patient study were undertaken to evaluate the feasibility of magnetic resonance (MR) colonography with a 1.0-T system.
An ex vivo colon model was scanned. A cleaned pig colon was prepared with six simulated sessile polyps (diameters of 4-12 mm) and one simulated pedunculated polyp (diameter of 5 mm). Subsequently, five patients (aged 39-81 years; four women, one man) were examined with MR colonography, immediately followed by endoscopic colonoscopy. After preparation for colonoscopy, the colon was filled with a Gd-DTPA/water solution (1:100). A breath-hold 3D gradient-echo sequence was acquired in both the prone and supine positions and after intravenous Gd-DTPA administration. Images were analyzed interactively by using multiplanar projections, maximum-intensity projection, and a virtual endoscopic view. The MR results were compared with the findings of the fiberoptic endoscopy.
All seven simulated lesions of the colon model could be detected by MR imaging. In one patient, an advanced colon cancer as well as an additional small polyp was depicted. In the other four patients, single polyps with a diameter of 1 to 2.5 cm and a large adenoma were visualized by MR colonography. Contrast enhancement of the polyps was noted only after subtraction.
The 1.0-T system is feasible for MR colonography. Reduced requirements for hardware could contribute to establish the novel technique as a screening method for colorectal polyps.
进行了一项体外研究以及一项临床前瞻性患者研究，以评估使用1.0-T系统进行磁共振（MR）结肠成像的可行性。
对一个体外结肠模型进行扫描。准备一个清洁的猪结肠，其中有六个模拟的无蒂息肉（直径4 - 12毫米）和一个模拟的有蒂息肉（直径5毫米）。随后，对五名患者（年龄39 - 81岁；四名女性，一名男性）进行MR结肠成像检查，紧接着进行内镜结肠镜检查。在为结肠镜检查做准备后，结肠用钆喷酸葡胺/水溶液（1:100）充盈。在俯卧位和仰卧位以及静脉注射钆喷酸葡胺后，采集屏气三维梯度回波序列图像。通过多平面投影、最大强度投影和虚拟内镜视图对图像进行交互式分析。将MR结果与纤维内镜检查结果进行比较。
MR成像能够检测出结肠模型的所有七个模拟病变。在一名患者中，显示出一例进展期结肠癌以及另外一个小息肉。在其他四名患者中，MR结肠成像显示出直径为1至2.5厘米的单个息肉和一个大腺瘤。仅在相减后才注意到息肉的对比增强。
1.0-T系统用于MR结肠成像是可行的。对硬件要求的降低可能有助于将这项新技术确立为结直肠息肉的筛查方法。
