对人类中与小鼠T位点相对应物的寻找——脊柱裂患者HL - A类型研究的阴性结果
The search for a human equivalent of the mouse T-locus - negative results from a study of HL-A types in spina bifida.
作者信息
Bobrow M, Bodmer J G, Bodmer W F, McDevitt H O, Lorber J, Swift P
出版信息
Tissue Antigens. 1975 May;5(4):234-7. doi: 10.1111/j.1399-0039.1975.tb01469.x.
Abstract
The spina bifida/anencephaly complex in man in some ways resembles the effects of T-locus mutants in the mouse. To test the hypothesis that these entities are genetically related, HL-A typing was performed in families with multiple cases of central nervous system abnormality. No evidence of linkage was found between HL-A type and the congenital malformation.
摘要
人类脊柱裂/无脑儿综合征在某些方面类似于小鼠T位点突变体的效应。为了检验这些病症在遗传上相关的假说，对有多例中枢神经系统异常的家庭进行了HL - A分型。未发现HL - A类型与先天性畸形之间存在连锁的证据。
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