人类白细胞抗原共享、复发性自然流产与遗传假说
HLA-sharing, recurrent spontaneous abortion, and the genetic hypothesis.
作者信息
Hedrick P W
机构信息
Division of Biological Sciences, University of Kansas, Lawrence 66045.
出版信息
Genetics. 1988 May;119(1):199-204. doi: 10.1093/genetics/119.1.199.
Abstract
A number of studies indicates that there is a high sharing of HLA antigens in couples having recurrent spontaneous abortions. The genetic hypothesis to explain this phenomenon suggests that this fetal loss results from homozygosity of recessive lethal or deleterious alleles in gametic disequilibrium with HLA antigens. Theory predicting the lethality rate is derived when antigens are shared at one, two or three loci, given that the disequilibrium is absolute. In addition, the effects of partial disequilibrium, inbreeding, and segregation distortion on the lethal proportion are examined.
摘要
多项研究表明，反复自然流产的夫妇中HLA抗原的共享率很高。解释这一现象的遗传假说认为，这种胎儿丢失是由于与HLA抗原处于配子不平衡状态的隐性致死或有害等位基因的纯合性所致。在不平衡是绝对的情况下，当抗原在一个、两个或三个位点共享时，推导出预测致死死致死率的理论。此外，还研究了部分不平衡、近亲繁殖和分离畸变对致死比例的影响。
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