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本文引用的文献

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Immunogenetics of spontaneous abortions in humans.人类自然流产的免疫遗传学
Transplantation. 1983 Jan;35(1):1-6.
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Maternal-paternal histocompatibility: lack of association with habitual abortions.母婴组织相容性：与习惯性流产无关。
Fertil Steril. 1984 Sep;42(3):389-95. doi: 10.1016/s0015-0282(16)48078-7.
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Possible human analogs of the murine T/t complex.小鼠T/t复合体可能的人类类似物。
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A comprehensive search for segregation distortion in HLA.对HLA中分离畸变的全面搜索。
Hum Immunol. 1987 Feb;18(2):163-80. doi: 10.1016/0198-8859(87)90013-9.
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Segregation of HLA A,B haplotypes and the distribution of antigen mismatches between mother and offspring in Hutterite families.哈特教派家庭中HLA A、B单倍型的分离以及母婴之间抗原错配的分布情况。
Am J Hum Genet. 1986 Jun;38(6):971-7.
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The limits of ascertainment.确定的限度。
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7
Maternal-fetal interactions and the maintenance of HLA polymorphism.母胎相互作用与HLA多态性的维持
Genetics. 1988 May;119(1):205-12. doi: 10.1093/genetics/119.1.205.
8
HLA sharing and spontaneous abortion in humans.人类中的HLA共享与自然流产
Am J Obstet Gynecol. 1985 Apr 15;151(8):1053-8. doi: 10.1016/0002-9378(85)90379-5.
9
The search for a human equivalent of the mouse T-locus - negative results from a study of HL-A types in spina bifida.对人类中与小鼠T位点相对应物的寻找——脊柱裂患者HL - A类型研究的阴性结果
Tissue Antigens. 1975 May;5(4):234-7. doi: 10.1111/j.1399-0039.1975.tb01469.x.
10
Dynamics of correlated genetic systems. I. Selection in the region of the Glued locus of Drosophila melanogaster.相关遗传系统的动力学。I. 黑腹果蝇黏合基因座区域的选择
Genetics. 1976 Aug;83(4):793-810. doi: 10.1093/genetics/83.4.793.

人类白细胞抗原共享、复发性自然流产与遗传假说

HLA-sharing, recurrent spontaneous abortion, and the genetic hypothesis.

作者信息

Hedrick P W

机构信息

Division of Biological Sciences, University of Kansas, Lawrence 66045.

出版信息

Genetics. 1988 May;119(1):199-204. doi: 10.1093/genetics/119.1.199.

DOI:10.1093/genetics/119.1.199
PMID:3396862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1203339/
Abstract

A number of studies indicates that there is a high sharing of HLA antigens in couples having recurrent spontaneous abortions. The genetic hypothesis to explain this phenomenon suggests that this fetal loss results from homozygosity of recessive lethal or deleterious alleles in gametic disequilibrium with HLA antigens. Theory predicting the lethality rate is derived when antigens are shared at one, two or three loci, given that the disequilibrium is absolute. In addition, the effects of partial disequilibrium, inbreeding, and segregation distortion on the lethal proportion are examined.

摘要

多项研究表明，反复自然流产的夫妇中HLA抗原的共享率很高。解释这一现象的遗传假说认为，这种胎儿丢失是由于与HLA抗原处于配子不平衡状态的隐性致死或有害等位基因的纯合性所致。在不平衡是绝对的情况下，当抗原在一个、两个或三个位点共享时，推导出预测致死死致死率的理论。此外，还研究了部分不平衡、近亲繁殖和分离畸变对致死比例的影响。