Cravioto H
Acta Neuropathol Suppl. 1975;Suppl 6:135-40. doi: 10.1007/978-3-662-08456-4_23.
The histology and ultrastructure of primary central nervous system and metastatic (epidural) reticulum cell sarcoma is described. The tumors showed varying numbers of argyrophilic microglial cells which in all cases constituted a minority of all tumor cells. A primitive, undifferentiated cell, common to all tumors, was a small cell with a large dense nucleus and a narrow rim of poorly structured cytoplasm. These cells frequently showed small fatty inclusions and were tentatively identified as primitive multipotential cells from which all other tumor cells develop. It is concluded that reticulum cell sarcoma of the nervous system (primary or metastatic) and microglioma or microgliomatosis are one and the same tumor.
本文描述了原发性中枢神经系统和转移性（硬膜外）网状细胞肉瘤的组织学和超微结构。肿瘤显示出数量不等的嗜银性小胶质细胞，在所有病例中，这些细胞在所有肿瘤细胞中占少数。所有肿瘤共有的一种原始、未分化细胞是一种小细胞，核大而致密，细胞质边缘狭窄且结构不佳。这些细胞经常显示出小的脂肪包涵体，并初步鉴定为所有其他肿瘤细胞由此发育而来的原始多能细胞。结论是神经系统的网状细胞肉瘤（原发性或转移性）与小胶质细胞瘤或小胶质细胞增生症是同一肿瘤。
