Kepes J J, Kepes M
Acta Neuropathol Suppl. 1975;Suppl 6:75-9. doi: 10.1007/978-3-662-08456-4_12.
Authors review differences between CNS and extraneural reticuloses, and consider the immediate threat to life by CNS lymphomas contrasting to other organ lymphomas, which usually become fatal only after generalization. Other special features of CNS reticuloses include the role of microglial cells, reactive astrocytosis, variations in meningeal vs. parenchymatous involvement and easier morphologic confusion with inflammatory processes. Analogies exist between CNS and extranodal "organ" lymphomas in terms of relatively late or no generalization. The entire spectrum of lymphomatous and histiocytic proliferation may occur in the CNS, the latter including atypical fibrous xanthomas and xanthosarcomas. A further analogy is seen in the presence of lymphocyte and plasma cells in cerebral and organ lymphomas that may well represent host defense reaction. When present in large numbers they may be responsible for the "inflammatory" appearance of some reticulum cell sarcomas of the brain.
作者回顾了中枢神经系统（CNS）网状细胞增多症与神经外网状细胞增多症之间的差异，并认为与其他器官淋巴瘤相比，CNS淋巴瘤对生命构成直接威胁，其他器官淋巴瘤通常仅在广泛播散后才会致命。CNS网状细胞增多症的其他特殊特征包括小胶质细胞的作用、反应性星形细胞增生、脑膜与实质受累的差异以及与炎症过程在形态学上更容易混淆。在相对较晚发生或不发生广泛播散方面，CNS与结外“器官”淋巴瘤存在相似之处。淋巴瘤和组织细胞增生的整个谱系都可能发生在CNS中，后者包括非典型纤维性黄色瘤和黄色肉瘤。在脑淋巴瘤和器官淋巴瘤中存在淋巴细胞和浆细胞，这很可能代表宿主防御反应，这是另一个相似之处。当它们大量存在时，可能是导致一些脑网状细胞肉瘤出现“炎症”表现的原因。
