Linberg U, Jodal U, Hanson L A, Kaijser B
Acta Paediatr Scand. 1975 Jul;64(4):574-80. doi: 10.1111/j.1651-2227.1975.tb03885.x.
As no method for localization of urinary tract infection has been shown to be absolutely reliable, six methods have been run parallelly in a study of 60 school girls with asymptomatic bacteriuria caused by E. coli. A poor correlation was obtained between "high infection" indicated by bladder washout test and abnormal findings of C-reactive protein, sedimentation rate, antibody titres or renal concentrating capacity, while findings of parenchymal reduction on the pyelogram and reflux on the urethrocystogram were often found within this group. The low frequency of abnormal findings of C-reactive protein, sedimentation rate and renal concentrating capacity in girls with a "high infection" may be explained by the finding that the ABU patients were infected with changed E. coli strains probably not able to cause the usual inflammatory reactions. The patients' bacteria were found to be less efficient in providing antigen for antibody determinations than were standard strains of same O group, indicating a difference between strains from ABU patients and standard strains. From the battery of tests used it seemed that most of the girls had a bladder infection. All tests were normal in 48% of the patients while at least three of the methods were abnormal in 12%.
由于尚未证明任何一种尿路感染定位方法是绝对可靠的，因此在一项针对60名由大肠杆菌引起无症状菌尿的女学生的研究中，同时运用了六种方法。膀胱冲洗试验显示的“高度感染”与C反应蛋白、血沉、抗体滴度或肾脏浓缩功能的异常结果之间相关性较差，而肾盂造影显示的实质减少以及尿道膀胱造影显示的反流现象在该组中却经常出现。“高度感染”的女孩中C反应蛋白、血沉和肾脏浓缩功能异常结果的低发生率，可能是由于发现无症状菌尿患者感染的是变异的大肠杆菌菌株，可能无法引发常见的炎症反应。发现患者的细菌在为抗体测定提供抗原方面比相同O组的标准菌株效率更低，这表明无症状菌尿患者的菌株与标准菌株存在差异。从所使用的一系列检测来看，似乎大多数女孩患有膀胱感染。48%的患者所有检测结果均正常，而12%的患者至少有三种方法检测结果异常。
