促红细胞生成素可穿过血脑屏障，以预防实验性脑损伤。
Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury.
作者信息
Brines M L, Ghezzi P, Keenan S, Agnello D, de Lanerolle N C, Cerami C, Itri L M, Cerami A
机构信息
The Kenneth S. Warren Laboratories, 765 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
出版信息
Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10526-31. doi: 10.1073/pnas.97.19.10526.
Abstract
Erythropoietin (EPO), recognized for its central role in erythropoiesis, also mediates neuroprotection when the recombinant form (r-Hu-EPO) is directly injected into ischemic rodent brain. We observed abundant expression of the EPO receptor at brain capillaries, which could provide a route for circulating EPO to enter the brain. In confirmation of this hypothesis, systemic administration of r-Hu-EPO before or up to 6 h after focal brain ischemia reduced injury by approximately 50-75%. R-Hu-EPO also ameliorates the extent of concussive brain injury, the immune damage in experimental autoimmune encephalomyelitis, and the toxicity of kainate. Given r-Hu-EPO's excellent safety profile, clinical trials evaluating systemically administered r-Hu-EPO as a general neuroprotective treatment are warranted.
摘要
促红细胞生成素（EPO）因其在红细胞生成中的核心作用而闻名，当将重组形式的促红细胞生成素（r-Hu-EPO）直接注入缺血的啮齿动物大脑时，它还介导神经保护作用。我们观察到脑毛细血管处促红细胞生成素受体的大量表达，这可能为循环中的促红细胞生成素进入大脑提供一条途径。为证实这一假设，在局灶性脑缺血前或缺血后6小时内全身给予r-Hu-EPO可使损伤减少约50%-75%。r-Hu-EPO还可改善脑震荡性损伤的程度、实验性自身免疫性脑脊髓炎中的免疫损伤以及海藻酸盐的毒性。鉴于r-Hu-EPO具有出色的安全性，有必要进行临床试验来评估全身给予r-Hu-EPO作为一种通用的神经保护治疗方法的效果。
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