Bickford P C, Breiderick L
Department of Veterans Affairs Medical Center, Research Service (151), 1055 Clermont Street, Denver, CO 80220, USA.
Neurosci Lett. 2000 Sep 22;291(3):187-90. doi: 10.1016/s0304-3940(00)01417-8.
During the aging process there is a decline in the function of many central nervous system receptor systems. In this report we examine the ability of midazolam to potentiate gamma-aminobutyric acid (GABA) mediated inhibition recorded from cerebellar Purkinje neurons using extracellular recording methods. We report that when midazolam is applied concurrently with GABA from glass multibarrel electrodes that midazolam potentiates GABA mediated inhibition in 46% of Purkinje neurons in 3-month-old F344 rats, 63% of neurons in 18-month-old F344 rats and 54% of cells in 24-month-old F344 rats. Thus, there is no age related decline in function of this response. In fact, the response to midazolam is significantly increased in 18-month-old rats.
在衰老过程中，许多中枢神经系统受体系统的功能会下降。在本报告中，我们使用细胞外记录方法研究了咪达唑仑增强小脑浦肯野神经元记录到的γ-氨基丁酸（GABA）介导的抑制作用的能力。我们报告，当从玻璃多管电极同时施加咪达唑仑和GABA时，咪达唑仑在3个月大的F344大鼠中增强了46%的浦肯野神经元的GABA介导的抑制作用，在18个月大的F344大鼠中增强了63%的神经元，在24个月大的F344大鼠中增强了54%的细胞。因此，这种反应的功能没有与年龄相关的下降。事实上，18个月大的大鼠对咪达唑仑的反应显著增加。
