Gould T J, Bickford P C
Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262, USA.
Neurosci Lett. 1996 Sep 20;216(1):53-6. doi: 10.1016/0304-3940(96)13007-x.
Female Fischer 344 (F344) rats were tested for age-related differences in both cerebellar beta-adrenergic receptor activation and motor learning. Three and 20 month old rats were tested on a motor learning paradigm that required the rats to adjust their gait to navigate a runway of unevenly spaced pegs. Rates of acquisition were compared between age groups. After behavioral testing, cerebellar beta-adrenergic receptor function was assessed using extracellular recordings of Purkinje cells during iontophoresis of GABA and isoproterenol (ISO). Aged female rats showed deficits in motor learning and in beta-adrenergic receptor activation. In young rats, ISO modulated GABAergic inhibition of Purkinje cell firing in more cells compared with aged rats. Thus, aging produces deficits in both motor learning and in beta-adrenergic receptor activation in aged female F344 rats.
对雌性Fischer 344（F344）大鼠进行了小脑β-肾上腺素能受体激活和运动学习方面年龄相关差异的测试。对3个月和20个月大的大鼠进行了一项运动学习范式测试，该范式要求大鼠调整步态以在间隔不均匀的栓子跑道上导航。比较了不同年龄组之间的习得率。行为测试后，在γ-氨基丁酸（GABA）和异丙肾上腺素（ISO）离子电渗期间，使用浦肯野细胞的细胞外记录来评估小脑β-肾上腺素能受体功能。老年雌性大鼠在运动学习和β-肾上腺素能受体激活方面表现出缺陷。与老年大鼠相比，年轻大鼠中，ISO调节更多细胞中GABA能对浦肯野细胞放电的抑制。因此，衰老会导致老年雌性F344大鼠在运动学习和β-肾上腺素能受体激活方面出现缺陷。
