De las Heras Castaño G, García de la Paz A, Fernández M D, Fernández Forcelledo J L
Gastroenterology Service, Marqués de Valdecilla University Hospital, School of Medicine, Santander, Spain.
Rev Esp Enferm Dig. 2000 Jun;92(6):375-85.
The purpose of this report is to analyze the results of a 1-year clinical study of antioxidant therapy in the treatment of pain and recurrent inflammatory episodes in patients with chronic and acute recurrent pancreatitis, using a prospective, descriptive, pre-post, open design. The intensity of pain at the beginning and end of treatment was assessed with a visual analogue scale, and these results along with the number of hospital admissions for pancreatic disease were analyzed.
We studied patients with acute recurrent or chronic pancreatitis who had suffered from pain or acute inflammatory episodes the year before the beginning of treatment with a complex containing L-methionine, beta-carotene, vitamin C, vitamin E and organic selenium.
Of 10 patients with chronic pancreatitis who completed treatment, the intensity of pain was reduced considerably in 9 (61.5 +/- 21.5 mm vs. 19.6 +/- 26.1 mm, p = 0.03), and pain was completely absent in 3 of these patients. Twelve patients who completed treatment had fewer hospital admissions during the year with antioxidant treatment than they had had during the previous year (1.5 +/- 1.62 vs. 0.25 +/- 0.45 admissions, p = 0.03).
Antioxidant treatment had a positive effect in patients who suffered from pancreatic inflammatory pain, and its effectiveness should be tested before more aggressive and costlier treatments are considered.
本报告旨在分析一项为期1年的抗氧化治疗临床研究结果，该研究采用前瞻性、描述性、治疗前后对比的开放式设计，用于治疗慢性和急性复发性胰腺炎患者的疼痛及复发性炎症发作。使用视觉模拟量表评估治疗开始和结束时的疼痛强度，并对这些结果以及胰腺疾病的住院次数进行分析。
我们研究了在开始使用含有L-蛋氨酸、β-胡萝卜素、维生素C、维生素E和有机硒的复合物进行治疗前一年患有疼痛或急性炎症发作的急性复发性或慢性胰腺炎患者。
10例完成治疗的慢性胰腺炎患者中，9例疼痛强度显著降低（61.5±21.5毫米对19.6±26.1毫米，p = 0.03），其中3例患者疼痛完全消失。12例完成治疗的患者在接受抗氧化治疗的一年中住院次数少于上一年（1.5±1.62次对0.25±0.45次，p = 0.03）。
抗氧化治疗对患有胰腺炎性疼痛的患者有积极作用，在考虑更积极且成本更高的治疗之前，应先测试其有效性。
