Morris-Stiff G J, Bowrey D J, Oleesky D, Davies M, Clark G W, Puntis M C
Department of Surgery, University Hospital of Wales, Health Park, Cardiff, United Kingdom.
Am J Gastroenterol. 1999 Aug;94(8):2135-40. doi: 10.1111/j.1572-0241.1999.01311.x.
It has been suggested that patients with chronic pancreatitis have antioxidant deficiencies. It is unclear whether these antioxidant deficiencies also occur in patients with recurrent acute pancreatitis and whether this condition represents an intermediate state between normality and chronic pancreatitis. The aim of this study was to determine the antioxidant profiles of patients with pancreatitis (recurrent acute and chronic) and to compare their profiles with a control population.
The antioxidant profiles of patients with chronic pancreatitis (n = 27) and recurrent acute pancreatitis (n = 11) were determined and compared with the antioxidant profiles of control subjects (n = 19). The following parameters were measured in blood: trace elements (selenium, copper, zinc), vitamins A and E, and carotenoids (alpha-carotene, beta-carotene, xanthine, beta-cryptoxanthine, lycopene).
Patients with chronic pancreatitis had significantly lower plasma concentrations of selenium, vitamin A, vitamin E, beta-carotene, xanthine, beta-cryptoxanthine, and lycopene compared with both control subjects and patients with recurrent acute pancreatitis (p < 0.05). There were no significant differences between the antioxidant profiles of patients with chronic pancreatitis due to alcohol excess and patients with idiopathic chronic pancreatitis, or between the antioxidant profiles of patients with recurrent acute pancreatitis and control subjects.
Patients with chronic pancreatitis had evidence of multiple antioxidant deficiencies. The antioxidant profiles of patients with recurrent acute pancreatitis did not differ from those of control subjects, discounting the hypothesis that recurrent acute pancreatitis represents an intermediate state between normality and chronic pancreatitis.
有人提出慢性胰腺炎患者存在抗氧化剂缺乏的情况。目前尚不清楚这些抗氧化剂缺乏是否也存在于复发性急性胰腺炎患者中，以及这种情况是否代表正常状态与慢性胰腺炎之间的中间状态。本研究的目的是确定胰腺炎患者（复发性急性和慢性）的抗氧化剂谱，并将其与对照人群的谱进行比较。
测定慢性胰腺炎患者（n = 27）和复发性急性胰腺炎患者（n = 11）的抗氧化剂谱，并与对照受试者（n = 19）的抗氧化剂谱进行比较。检测血液中的以下参数：微量元素（硒、铜、锌）、维生素A和E以及类胡萝卜素（α-胡萝卜素、β-胡萝卜素、黄嘌呤、β-隐黄质、番茄红素）。
与对照受试者和复发性急性胰腺炎患者相比，慢性胰腺炎患者的血浆硒、维生素A、维生素E、β-胡萝卜素、黄嘌呤、β-隐黄质和番茄红素浓度显著降低（p < 0.05）。酒精性慢性胰腺炎患者与特发性慢性胰腺炎患者的抗氧化剂谱之间，以及复发性急性胰腺炎患者与对照受试者的抗氧化剂谱之间均无显著差异。
慢性胰腺炎患者有多种抗氧化剂缺乏的证据。复发性急性胰腺炎患者的抗氧化剂谱与对照受试者无异，这排除了复发性急性胰腺炎代表正常状态与慢性胰腺炎之间中间状态的假说。
