Muscoplat C C, Thoen C O, Chen A W, Rakich P M, Johnson D W
Am J Vet Res. 1975 Aug;36(08):1167-71.
Swine infected with Mycobacterium bovis and Mycobacterium avium were studied for development and specificity of lymphocyte immunostimulation and tuberculin skin reactivity to purified protein derivatives (PPD) of tuberculins. Lymphocytes from infected animals had maximal blastogenic responses to PPD prepared from the homologous organisms. The time of appearance of specifically sensitized lymphocytes was studied, as was the specificity of skin reactivity. In vitro lymphocyte responses of M avium serotype 1-infected swine to M avium serotype 1 PPD were greater than were the responses of M avium serotype 2-infected swine to the same antigen. Results indicate that the specific stimulation of sensitized lymphocytes might prove useful in the diagnosis of tuberculosis in swine and in differentiating infections due to different serotypes of M avium.
对感染牛分枝杆菌和鸟分枝杆菌的猪进行了研究，以观察淋巴细胞免疫刺激的发展和特异性，以及对结核菌素纯化蛋白衍生物（PPD）的结核菌素皮肤反应性。感染动物的淋巴细胞对同源生物体制备的PPD有最大的增殖反应。研究了特异性致敏淋巴细胞出现的时间以及皮肤反应性的特异性。1型鸟分枝杆菌感染的猪对1型鸟分枝杆菌PPD的体外淋巴细胞反应大于2型鸟分枝杆菌感染的猪对相同抗原的反应。结果表明，致敏淋巴细胞的特异性刺激可能有助于猪结核病的诊断以及区分由不同血清型鸟分枝杆菌引起的感染。
