Aggleton J P, Vann S D, Oswald C J, Good M
School of Psychology, Cardiff University, Wales, UK.
Hippocampus. 2000;10(4):466-74. doi: 10.1002/1098-1063(2000)10:4<466::AID-HIPO13>3.0.CO;2-Y.
A consideration of the cortical projections to the hippocampus provides a number of candidate regions that might provide distal sensory information needed for allocentric processing. Prominent among the input regions are the entorhinal cortex, the perirhinal cortex, the postrhinal cortex, and the retrosplenial cortex. A review of these sites reveals the surprising fact that in spite of their anatomical connections, removal of the perirhinal and postrhinal cortices has little or no effect on spatial tasks and hence does not functionally disconnect the hippocampus. Extensive retrosplenial lesions have only mild effects, and even lesions of the entorhinal cortex only partially mimic the effects of hippocampal lesions upon tests of spatial memory. In contrast, studies using c-fos imaging support the involvement of the entorhinal, postrhinal, and retrosplenial cortices, but not the perirhinal cortex. It is argued that there exist multiple aspects of spatial memory, and this is reflected in the multiple routes by which cortical information can reach the hippocampus. One consequence is that lesions in a single site often have surprisingly mild effects on standard spatial tests.
对投射至海马体的皮质进行考量，可发现一些可能提供心向加工所需远端感觉信息的候选区域。输入区域中较为突出的是内嗅皮质、嗅周皮质、嗅后皮质和压后皮质。对这些部位的综述揭示了一个惊人的事实：尽管存在解剖学联系，但切除嗅周皮质和嗅后皮质对空间任务几乎没有影响，因此在功能上并未使海马体与其他部位断开连接。广泛的压后皮质损伤仅有轻微影响，甚至内嗅皮质损伤在空间记忆测试中也只是部分模拟了海马体损伤的效果。相比之下，使用c - fos成像的研究支持内嗅皮质、嗅后皮质和压后皮质参与其中，但不包括嗅周皮质。有人认为空间记忆存在多个方面，这反映在皮质信息到达海马体的多条路径上。一个结果是，单个部位的损伤通常对标准空间测试的影响出奇地轻微。
