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3例耐多药肺炎球菌所致菌血症性肺炎患者，使用阿奇霉素治疗失败，而使用左氧氟沙星治疗成功。

Bacteremic pneumonia due to multidrug-resistant pneumococci in 3 patients treated unsuccessfully with azithromycin and successfully with levofloxacin.

作者信息

Fogarty C, Goldschmidt R, Bush K

机构信息

Spartanburg Regional Health Care System, Spartanburg, South Carolina, USA.

出版信息

Clin Infect Dis. 2000 Aug;31(2):613-5. doi: 10.1086/313976.

DOI:10.1086/313976
PMID:10987733
Abstract

Three patients with bacteremic pneumonia caused by multidrug-resistant Streptococcus pneumoniae were treated unsuccessfully with azithromycin. One S. pneumoniae isolate carried a mef determinant for an efflux pump; a second isolate had an erm determinant. All 3 patients were successfully treated with levofloxacin, an antipneumococcal fluoroquinolone.

摘要

三名由耐多药肺炎链球菌引起菌血症性肺炎的患者接受阿奇霉素治疗未成功。一株肺炎链球菌分离株携带一个与外排泵有关的mef决定簇；另一株分离株有一个erm决定簇。所有3名患者均接受抗肺炎球菌氟喹诺酮类药物左氧氟沙星成功治疗。

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Bacteremic pneumonia due to multidrug-resistant pneumococci in 3 patients treated unsuccessfully with azithromycin and successfully with levofloxacin.3例耐多药肺炎球菌所致菌血症性肺炎患者，使用阿奇霉素治疗失败，而使用左氧氟沙星治疗成功。
Clin Infect Dis. 2000 Aug;31(2):613-5. doi: 10.1086/313976.
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Resistance to levofloxacin and failure of treatment of pneumococcal pneumonia.对左氧氟沙星的耐药性与肺炎球菌肺炎治疗失败
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Therapeutic options among broad-spectrum beta-lactams for infections caused by levofloxacin-nonsusceptible Streptococcus pneumoniae.针对左氧氟沙星不敏感的肺炎链球菌所致感染，在广谱β-内酰胺类药物中的治疗选择。
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Reply to: Efficacy and pharmacodynamics of simulated human-like treatment with levofloxacin on experimental pneumonia induced with penicillin-resistant pneumococci with various susceptibilities to fluoroquinolones.回复：左氧氟沙星模拟类人治疗对不同氟喹诺酮敏感性的耐青霉素肺炎球菌所致实验性肺炎的疗效及药效学研究
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