通过闭环复分解反应合成环肽。

Synthesis of cyclic peptides by ring-closing metathesis.

作者信息

Reichwein J F, Versluis C, Liskamp R M

机构信息

Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.

出版信息

J Org Chem. 2000 Sep 22;65(19):6187-95. doi: 10.1021/jo000759t.

DOI:10.1021/jo000759t

PMID:10987958

Abstract

The synthesis of a series of "amide to amide" cyclized peptides by ring-closing metathesis (RCM) as well as a convenient synthesis for the linear precursors is described. In addition, the influence of the length of the alkene substituents and the influence of the peptide sequence is investigated, leading to a set of general rules to obtain "amide to amide" cyclized peptides by RCM.

摘要

描述了通过闭环复分解反应（RCM）合成一系列“酰胺到酰胺”环化肽以及线性前体的简便合成方法。此外，研究了烯烃取代基长度和肽序列的影响，得出了一套通过RCM获得“酰胺到酰胺”环化肽的通用规则。