Prabhakaran E N, Rao I Nageswara, Boruah Anima, Iqbal Javed
Department of Chemistry, Indian Institute of Technology, Kanpur 208 016, India.
J Org Chem. 2002 Nov 15;67(23):8247-50. doi: 10.1021/jo0200320.
A reverse turn induced (gamma/beta-turn) cyclization of tripeptides 1 can be performed in a ring closing metathesis reaction with Grubbs' catalyst to the corresponding cyclic peptides 2. These cyclic peptides may be useful probes as a conformationally constrained mimic of the bioactive conformation of structurally related HIV protease inhibitors.
三肽1可通过与格拉布催化剂进行闭环复分解反应，引发反向转折诱导（γ/β-转折）环化反应生成相应的环肽2。这些环肽作为结构相关HIV蛋白酶抑制剂生物活性构象的构象受限模拟物，可能是有用的探针。
