Agbim O G
Chemotherapy. 1975;21 Suppl 1:68-75. doi: 10.1159/000221893.
A double-blind comparative clinical trial of doxycycline (200 mg on the first day followed by 100 mg daily for a total of 7 days) and ampicillin (250 mg 4 times daily for 7 days) was performed in 44 patients with acute or chonic sinusitis. Significantly superior results were observed with doxycycline; 90% of the patients responded to doxycycline and 35% to ampicillin. The incidence of side-effects was low and these were of a minor nature, in no case with either drug was discontinuance of treatment necessary. These results imply that in treating chronic bronchitis an antibiotic should be given which is effective not only against the responsible organisms but which is able also to penetrate those tissues (such as the sinuses) that act as a reservoir for these organisms. Doxycycline meets these requirements.
对44例急慢性鼻窦炎患者进行了一项多西环素（首日200mg，随后每日100mg，共7天）与氨苄西林（每日4次，每次250mg，共7天）的双盲对比临床试验。多西环素的效果显著优于氨苄西林；90%的患者对多西环素有效，对氨苄西林有效的患者为35%。副作用发生率低，且症状轻微，两种药物均无需停药。这些结果表明，在治疗慢性支气管炎时，应给予一种不仅对致病微生物有效，而且还能穿透作为这些微生物储存库的组织（如鼻窦）的抗生素。多西环素符合这些要求。
