Serembe M
Chemotherapy. 1975;21 Suppl 1:121-9. doi: 10.1159/000221898.
23 physicians in Italy took part in a multi-centre clinical trial of doxycycline in the treatment of respiratory tract infections. The case records of 290 patients were assessed with respect to both subjective and objective improvement and clinical cure: most patients were considered improved by the third day and cured by the fifth. The recommended dose of doxycycline was 200 mg on the first day and 100 mg daily thereafter; only 11 of the patients had to continue treatment beyond the tenth day. The antibiotic was extremely well tolerated; gastrointestinal side-effects occurred in 10 patients. Overall, 88.6% of the patients achieved a very good or good result.
23名意大利医生参与了一项多中心临床试验，该试验旨在研究强力霉素治疗呼吸道感染的效果。研究人员评估了290名患者的病例记录，包括主观和客观改善情况以及临床治愈情况：大多数患者在第三天时症状有所改善，第五天时治愈。强力霉素的推荐剂量为第一天200毫克，之后每天100毫克；只有11名患者需要在第十天后继续治疗。这种抗生素的耐受性非常好；10名患者出现了胃肠道副作用。总体而言，88.6%的患者取得了非常好或良好的治疗效果。
