Berwaerts J, Moorkens G, Abs R
Department of Endocrinology, Middelheim Hospital, Antwerp, Belgium.
Growth Horm IGF Res. 1998 Apr;8 Suppl B:127-9. doi: 10.1016/s1096-6374(98)80036-1.
Decreased serum levels of insulin-like growth factor I (IGF-I) are common in patients with fibromyalgia, which is frequently associated with chronic fatigue syndrome (CFS). Twenty patients with CFS (7 men, 13 women; age range, 30-60 years) and age- and sex-matched controls were tested for peak GH responses to insulin-induced hypoglycaemia and arginine administration. Nocturnal secretion of GH and serum levels of IGF-I were also measured. Serum IGF-I SDS (+/- SD) was significantly lower in patients with CFS than in controls (SDS, -0.39 +/- 1.07 vs 0.33 +/- 0.84; P = 0.02). Patients with CFS also tended to have reduced nocturnal secretion of GH (area under the curve, 32.4 +/- 18.3 vs 62.7 +/- 43.7 microg/l/15 minutes; P= 0.06), but peak GH responses to insulin-induced hypoglycaemia and arginine administration did not differ significantly between the two groups. It is not clear whether the tendency for impaired spontaneous nocturnal GH secretion in patients with CFS is a cause or an effect of the condition.
胰岛素样生长因子I（IGF-I）血清水平降低在纤维肌痛患者中很常见，而纤维肌痛常与慢性疲劳综合征（CFS）相关。对20例CFS患者（7例男性，13例女性；年龄范围30 - 60岁）以及年龄和性别匹配的对照组进行了胰岛素诱导低血糖和精氨酸给药后生长激素（GH）峰值反应测试。还测量了GH的夜间分泌及IGF-I的血清水平。CFS患者的血清IGF-I SDS（±标准差）显著低于对照组（SDS，-0.39±1.07对0.33±0.84；P = 0.02）。CFS患者的GH夜间分泌也往往减少（曲线下面积，32.4±18.3对62.7±43.7微克/升/15分钟；P = 0.06），但两组之间胰岛素诱导低血糖和精氨酸给药后的GH峰值反应无显著差异。目前尚不清楚CFS患者夜间自发性GH分泌受损的倾向是该疾病的原因还是结果。
