阿的平、氯喹和伯氨喹对麻风分枝杆菌在小鼠体内增殖的影响。
Effect of quinacrine, chloroquine and primaquine on the multiplication of Mycobacterium leprae in mice.
作者信息
Pattyn S R, Loo G V
出版信息
Int J Lepr Other Mycobact Dis. 1975 Jan-Mar;43(1):14-5.
PMID:1099017
Abstract
Quinacrine administered in 100 mg per kg body weight to mice had a bacteriostatic activity on M. leprae in the mouse, chloroquine at 15 mg per kg and primaquine at 0.25 mg per kg were without activity. These findings could point to the presence of a functioning direct oxidative pathway of glucose catabolism in M. leprae.
摘要
给小鼠按每千克体重100毫克的剂量施用奎纳克林，对小鼠体内的麻风杆菌有抑菌活性，而按每千克体重15毫克的剂量施用氯喹和按每千克体重0.25毫克的剂量施用伯氨喹则无活性。这些发现可能表明麻风杆菌中存在葡萄糖分解代谢的有效直接氧化途径。
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