Jansen T, Romiti R
Department of Dermatology, Ludwig-Maximilians-University of Munich, Munich, Germany.
Pediatr Dermatol. 2000 Jul-Aug;17(4):282-5. doi: 10.1046/j.1525-1470.2000.01775.x.
Progeria infantum (Hutchinson-Gilford syndrome) is a very rare syndrome of premature aging characterized by growth retardation and specific, progressive, premature senescent changes of the skin and other tissues. We report a 1.5-year-old girl with loss of scalp hair, eyebrows, and lashes, prominent scalp veins, micrognathia, abnormal ears, loss of subcutaneous tissue, and scleroderma-like areas over the trunk. Radiographic studies revealed coxa valga and acro-osteolysis of the terminal phalanges. The clinical and radiologic features corresponded well with progeria infantum.
婴儿早老症（哈钦森-吉尔福德综合征）是一种极为罕见的早衰综合征，其特征为生长发育迟缓以及皮肤和其他组织出现特定的、进行性的早衰变化。我们报告了一名1.5岁女童，她出现头皮毛发、眉毛和睫毛脱落，头皮静脉突出，小颌畸形，耳部异常，皮下组织缺失以及躯干出现硬皮病样区域。影像学研究显示髋外翻和末节指骨骨质溶解。临床和放射学特征与婴儿早老症高度相符。
