Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, "Dunărea de Jos" University, Galaţi, Romania.
Multidisciplinary Integrated Center of Dermatological Interface Research MIC-DIR (Centrul Integrat Multidisciplinar de Cercetare de Interfata Dermatologica - CIM-CID), "Dunărea de Jos" University, Galaţi, Romania.
Front Immunol. 2023 Jul 12;14:1180221. doi: 10.3389/fimmu.2023.1180221. eCollection 2023.
Scleroderma-like cutaneous lesions have been found in many pathological conditions and they have the clinical appearance of sclerotic or scleroatrophic lesions. Affected skin biopsies described histopathological changes similar to those of scleroderma located strictly on the skin or those of systemic sclerosis. These skin lesions can be found in inflammatory diseases with autoimmune substrate (generalized morphea, chronic graft versus host disease, eosinophilic fasciitis), tissue storage diseases (scleredema, scleromyxedema, nephrogenyc systemic fibrosis, systemic amyloidosis), metabolic diseases (porphyrya cutanea tarda, phenylketonuria, hypothyroidism, scleredema diabeticorum), progeroid syndromes. Given the multiple etiologies of sclerodermal lesions, a correct differential diagnosis is necessary to establish the appropriate treatment.
硬皮病样皮肤损害可见于多种病理情况，其临床表现为硬化或硬化性病变。描述的皮肤活检组织病理学改变与硬皮病相似，位于皮肤或系统性硬皮病的皮肤严格。这些皮肤损害可见于具有自身免疫基础的炎症性疾病（泛发性硬斑病、慢性移植物抗宿主病、嗜酸性筋膜炎）、组织贮积病（硬肿病、硬皮黏液水肿、嗜酸性筋膜炎、肾源性全身纤维化为化、系统性淀粉样变性）、代谢性疾病（迟发性皮肤卟啉病、苯丙酮尿症、甲状腺功能减退症、糖尿病性硬肿病）、进行性综合征。鉴于硬皮病样皮肤损害的多种病因，需要进行正确的鉴别诊断以确定适当的治疗。
