Drasdo D
Institut für Medizinische Informatik, Statistik und Epidemiologie, Universität Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany.
Phys Rev Lett. 2000 May 1;84(18):4244-7. doi: 10.1103/PhysRevLett.84.4244.
Growth and folding in one-layered model tissue sheets are studied in a stochastic, lattice-free single cell model which considers the discrete cellular structure of the tissue, and in a coarse grained analytical approach. The polarity of the one-layered tissue is considered by a bending term. Cell division gives rise to a locally increasing metric. An exponential and a power-law growth regime are identified. In both regimes, folding occurs as soon as the bending contribution becomes too small to compensate the destabilizing effect of the cell proliferation. The potential biological relevance is discussed.
在一个随机的、无晶格的单细胞模型中研究了单层模型组织片的生长和折叠，该模型考虑了组织的离散细胞结构，并采用了粗粒度分析方法。通过一个弯曲项来考虑单层组织的极性。细胞分裂导致局部度量增加。确定了指数增长和幂律增长模式。在这两种模式下，一旦弯曲贡献变得太小而无法补偿细胞增殖的不稳定效应，就会发生折叠。讨论了其潜在的生物学相关性。
