Hoiby N, Pers C, Johansen H K, Hansen H
Department of Clinical Microbiology, Rigshospitalet, University of Copenhagen, Denmark.
Antimicrob Agents Chemother. 2000 Oct;44(10):2855-7. doi: 10.1128/AAC.44.10.2855-2857.2000.
The concentrations of beta-lactam antibiotics after standard doses were measured in blood and apocrine (axilla) and eccrine (forearm) sweat from six adult healthy persons. All persons had ceftazidime (axilla, 28.4 microg/ml; forearm, 11 microg/ml) and ceftriaxone (axilla, 8.9 microg/ml; forearm, 2.5 microg/ml) in sweat, and one person had cefuroxime in sweat (axilla, 7.8 microg/ml) (all data are mean peaks). Three persons had benzylpenicillin (axilla, 2.6 to 0.1 microg/ml) and one had phenoxymethylpenicillin (axilla, 0.4 microg/ml) in sweat. Excretion of beta-lactam antibiotics in the sweat may explain why staphylococci so rapidly become resistant to these drugs.
对6名成年健康人的血液、顶泌汗腺（腋窝）汗液和小汗腺（前臂）汗液中标准剂量的β-内酰胺类抗生素浓度进行了测量。所有受试者的汗液中均含有头孢他啶（腋窝，28.4微克/毫升；前臂，11微克/毫升）和头孢曲松（腋窝，8.9微克/毫升；前臂，2.5微克/毫升），1名受试者的汗液中含有头孢呋辛（腋窝，7.8微克/毫升）（所有数据均为平均峰值）。3名受试者的汗液中含有苄青霉素（腋窝，2.6至0.1微克/毫升），1名受试者的汗液中含有苯氧甲基青霉素（腋窝，0.4微克/毫升）。β-内酰胺类抗生素在汗液中的排泄可能解释了葡萄球菌为何如此迅速地对这些药物产生耐药性。
