吡喹酮与食物同时服用时生物利用度会增加。
Bioavailability of praziquantel increases with concomitant administration of food.
作者信息
Castro N, Medina R, Sotelo J, Jung H
机构信息
Instituto Nacional de Neurologia y Neurocirugia, Mexico City, Mexico.
出版信息
Antimicrob Agents Chemother. 2000 Oct;44(10):2903-4. doi: 10.1128/AAC.44.10.2903-2904.2000.
Abstract
In the present study we found that after a single oral dose of 1,800 mg of praziquantel, following a high-lipid diet and a high-carbohydrate diet, the maximum levels in plasma increased 243 and 515% and the area under the plasma concentration curve from 0 to 8 h increased 180 and 271%, respectively.
摘要
在本研究中，我们发现，单次口服1800毫克吡喹酮后，在高脂饮食和高碳水化合物饮食的情况下，血浆中的最高水平分别增加了243%和515%，血浆浓度曲线从0至8小时的曲线下面积分别增加了180%和271%。
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