Svensson C K, Edwards D J, Mauriello P M, Barde S H, Foster A C, Lanc R A, Middleton E, Lalka D
Clin Pharmacol Ther. 1983 Sep;34(3):316-23. doi: 10.1038/clpt.1983.174.
It has been suggested that alteration in the apparent oral bioavailability of propranolol taken with food may be due to a transient increase in QH. To investigate this hypothesis more closely, the time course of effect of a high-protein meal on QH was examined with the model compound ICG. Forty minutes postprandial, the mean increase in estimated QH was 69% above the control. QH was still elevated a mean of 36% at 100 min but by 280 min had decreased to a value that did not differ from control. Computer simulations were performed to predict the magnitude of change in the apparent oral bioavailability of propranolol that would be expected based on the observed QH changes. These simulations suggest that simple changes in QH alone cannot account for the increase in apparent oral bioavailability when propranolol is taken with food.
有人提出，与食物一起服用时普萘洛尔表观口服生物利用度的改变可能是由于肝血流量（QH）短暂增加所致。为了更深入地研究这一假设，用模型化合物吲哚菁绿（ICG）研究了高蛋白餐对QH的影响时间进程。餐后40分钟，估计的QH平均增加幅度比对照组高69%。在100分钟时，QH仍平均升高36%，但到280分钟时已降至与对照组无差异的值。进行了计算机模拟，以预测根据观察到的QH变化预期的普萘洛尔表观口服生物利用度的变化幅度。这些模拟表明，仅QH的简单变化不能解释普萘洛尔与食物一起服用时表观口服生物利用度的增加。
