Pascual A, Bruna I, Cerrolaza J, Moreno P, Ramos J T, Noriega A R, Delgado R
Department of Gynecology and Obstetrics, Hospital de Móstoles, Madrid, Spain.
Am J Obstet Gynecol. 2000 Sep;183(3):638-42. doi: 10.1067/mob.2000.106591.
The aim of this study was to evaluate the contribution of in utero infection to the vertical transmission of human immunodeficiency virus type 1 during the second trimester.
We examined fetal tissues from 21 second-trimester prostaglandin-induced abortions among human immunodeficiency virus type 1-infected women and compared the fetal vertical transmission rates with those among children born to human immunodeficiency virus-seropositive women. The presence of human immunodeficiency virus type 1 nucleic acid sequences was investigated with two different highly sensitive polymerase chain reaction techniques in tissue samples from the fetal thymus, lung, and brain.
No human immunodeficiency virus type 1 deoxyribonucleic acid was detected in any of the samples.
The absence of human immunodeficiency virus type 1 in all fetuses in our study is compatible with a low rate of maternal-fetal transmission during the second trimester of pregnancy.
本研究旨在评估子宫内感染对妊娠中期人类免疫缺陷病毒1型垂直传播的影响。
我们检查了21例妊娠中期因前列腺素诱导流产的人类免疫缺陷病毒1型感染女性的胎儿组织，并将胎儿垂直传播率与人类免疫缺陷病毒血清阳性女性所生孩子的垂直传播率进行比较。采用两种不同的高灵敏度聚合酶链反应技术，对胎儿胸腺、肺和脑的组织样本进行人类免疫缺陷病毒1型核酸序列检测。
所有样本均未检测到人类免疫缺陷病毒1型脱氧核糖核酸。
我们研究中所有胎儿均未感染人类免疫缺陷病毒1型，这与妊娠中期母胎传播率较低相符。
