用α-毒素类毒素进行免疫可在实验性金黄色葡萄球菌角膜炎期间保护角膜免受组织损伤。
Immunization with alpha-toxin toxoid protects the cornea against tissue damage during experimental Staphylococcus aureus keratitis.
作者信息
Hume E B, Dajcs J J, Moreau J M, O'Callaghan R J
机构信息
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
出版信息
Infect Immun. 2000 Oct;68(10):6052-5. doi: 10.1128/IAI.68.10.6052-6055.2000.
Abstract
Alpha-toxin is a major virulence factor in Staphylococcus aureus keratitis. Active or passive immunization with alpha-toxin toxoid could protect against corneal damage. Results show that either form of immunization did not kill bacteria but did significantly protect against corneal pathology, especially epithelial erosion.
摘要
α毒素是金黄色葡萄球菌角膜炎的主要毒力因子。用α毒素类毒素进行主动或被动免疫可预防角膜损伤。结果表明，两种免疫方式均不能杀死细菌，但能显著预防角膜病变，尤其是上皮糜烂。
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