Behrens G M, Meyer D, Stoll M, Schmidt R E
Department of Clinical Immunology, Hannover Medical School, Germany.
Immunobiology. 2000 Aug;202(2):186-93. doi: 10.1016/S0171-2985(00)80065-0.
Effective antiretroviral therapy leads to rapid decrease in plasma HIV-1 RNA, frequently followed by an increase in CD4 T-helper cell counts. The improvement of immune function during highly active antiretroviral therapy has important impact on natural history of AIDS-related opportunistic disorders. Here we describe cases of unusual clinical inflammatory syndromes in CMV retinitis, hepatitis C, and atypical mycobacteriosis in HIV-1 infected patients associated with the initiation of antiretroviral therapy. Pathogenetic implications and therapeutic management of these new immunopathologic syndromes are discussed.
有效的抗逆转录病毒疗法可使血浆中HIV-1 RNA迅速下降，随后CD4辅助性T细胞计数常常会增加。高效抗逆转录病毒疗法期间免疫功能的改善对艾滋病相关机会性疾病的自然病程具有重要影响。在此，我们描述了HIV-1感染患者在开始抗逆转录病毒治疗后出现的与巨细胞病毒性视网膜炎、丙型肝炎和非典型分枝杆菌病相关的不寻常临床炎症综合征病例。并讨论了这些新的免疫病理综合征的发病机制及治疗管理。
