Kocsard E
St Vincent's Hospital, Darlinghurst, New South Wales, Australia.
Australas J Dermatol. 1997 Jun;38 Suppl 1:S30. doi: 10.1111/j.1440-0960.1997.tb01005.x.
Solar keratoses belong to the list of clinically invisible dermatoses, as the loss of their horny layer may create the illusion that they have disappeared, and numerous subclinical lesions can be highlighted by 5-fluorouracil therapy. Solar keratoses are recognized as potential precursors for squamous cell carcinoma. However, basal cell carcinoma (BCC) may develop in a soft type of solar keratoses as a consequence of migration of pluripotential adnexal epithelial cells in reparative response to trauma, particularly in areas rich in adnexal structures, such as the face. These intraepithelial resident adnexal cells may result in the development of BCC following chronic solar exposure and damage.
日光性角化病属于临床不可见的皮肤病范畴，因为其角质层的缺失可能造成它们已消失的假象，并且5-氟尿嘧啶疗法可使众多亚临床损害显现出来。日光性角化病被认为是鳞状细胞癌的潜在前驱病变。然而，在柔软型日光性角化病中，由于多能性附属器上皮细胞在对创伤的修复反应中发生迁移，特别是在附属器结构丰富的区域（如面部），可能会发展为基底细胞癌（BCC）。这些上皮内的常驻附属器细胞在长期日光暴露和损伤后可能导致基底细胞癌的发生。
