Marks R, Rennie G, Selwood T
Anti-Cancer Council of Victoria, Carlton South, Melbourne, Australia.
Arch Dermatol. 1988 Jul;124(7):1039-42.
Six thousand four hundred sixteen people aged 40 years and over from three different locations in Victoria (Australia) were examined on the hands, forearms, head, and neck for the presence of solar keratoses and basal (BCCs) and squamous cell carcinomas (SCCs). Analysis of the relationship between these tumors revealed that the factors which predicted the likelihood of developing a solar keratosis were essentially the same as those that predicted the likelihood of developing a BCC and/or an SCC. These were age, sex, years of residence in Australia, indoor or outdoor occupation, tanning ability, propensity to sunburn, and location of residence. The presence of a coexisting solar keratosis was necessary for the development of an SCC in contrast to the development of a BCC. The findings suggest that unlike BCCs, the majority of SCCs in light-exposed areas may arise from preexisting solar keratoses. Whereas the prevalence of BCCs and SCCs was relatively constant in the three locations, the prevalence of solar keratoses differed markedly in direct relation to the degree of isolation. This suggests that solar keratoses are a more sensitive indicator of sunlight exposure than invasive carcinoma.
对来自澳大利亚维多利亚州三个不同地点的6416名40岁及以上人群的手部、前臂、头部和颈部进行了检查，以确定是否存在日光性角化病、基底细胞癌（BCC）和鳞状细胞癌（SCC）。对这些肿瘤之间关系的分析表明，预测发生日光性角化病可能性的因素与预测发生基底细胞癌和/或鳞状细胞癌可能性的因素基本相同。这些因素包括年龄、性别、在澳大利亚居住的年限、室内或室外工作、晒黑能力、晒伤倾向以及居住地点。与基底细胞癌的发生不同，鳞状细胞癌的发生需要同时存在日光性角化病。研究结果表明，与基底细胞癌不同，暴露于阳光下区域的大多数鳞状细胞癌可能起源于先前存在的日光性角化病。虽然基底细胞癌和鳞状细胞癌的患病率在这三个地点相对恒定，但日光性角化病的患病率与隔离程度直接相关，差异显著。这表明日光性角化病比浸润性癌是更敏感的阳光暴露指标。
