Muñoz-Cruzado Poce M J, García Navas A J, Moreno Gómez M L, Garratón Juliá R, Marcelo Martínez A, Madueño Caro A J
Centro de Salud Rodríguez de Arias, San Fernando, Cádiz.
Aten Primaria. 2000 Jul-Aug;26(3):176-9. doi: 10.1016/s0212-6567(00)78637-9.
To determine the prevalence of thyroid disorders in patients diagnosed with depression.
Cross-sectional descriptive study (random sampling).
Primary care, San Fernando (Cádiz).
Patients diagnosed with depression (DSM IV criteria) at the San Fernando Mental Health Centre.
108 patients were studied (95% CI; p = 11 +/- 5%), in whom figures for TSH in the blood, free T3 and T4 and anti-thyroid antibodies (anti-thyroglobulin and anti-TPO) were determined. We found a predominance of women among the patients studied (5:1) and only found thyroid disorders in women (100%). The age group with greatest frequency of depressive illness was from 50 to 59. 73.1% of all the thyroid disorders were found in the 30-59 age group. We detected a high number of depressive patients with unknown thyroid analytic disorder (24.1%) and a relevant prevalence of depressives with thyroid auto-immune disease (16.6%), especially due to positive anti-TPOs, exceeding the prevalence in previous studies. There was less hypothyroidism than expected (7.4% against 8-14%), although more than the estimated figure for the population as a whole (5%).
Indiscriminate thyroid tests on depressive patients, as a screening method, can be dispensed with. Given the results of anti-thyroid antibodies and the few studies of prevalence in the depressive population, it seems appropriate to conduct studies with a bigger sample and meta-analysis previous research.
确定诊断为抑郁症的患者中甲状腺疾病的患病率。
横断面描述性研究（随机抽样）。
圣费尔南多（加的斯）的初级保健机构。
在圣费尔南多心理健康中心被诊断为抑郁症（DSM-IV标准）的患者。
对108名患者进行了研究（95%置信区间；p = 11 +/- 5%），测定了他们血液中的促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（T3）、游离甲状腺素（T4）以及抗甲状腺抗体（抗甲状腺球蛋白和抗甲状腺过氧化物酶抗体）水平。我们发现所研究的患者中女性占主导（5:1），且仅在女性中发现了甲状腺疾病（100%）。抑郁症发病频率最高的年龄组为50至59岁。所有甲状腺疾病的73.1%出现在30至59岁年龄组。我们检测到大量甲状腺分析紊乱情况不明的抑郁症患者（24.1%）以及患有甲状腺自身免疫性疾病的抑郁症患者的相关患病率（16.6%），尤其是由于抗甲状腺过氧化物酶抗体呈阳性，这一患病率超过了以往研究。甲状腺功能减退症的发生率低于预期（7.4%，而预期为8 - 14%），尽管高于总体人群的估计发生率（5%）。
作为一种筛查方法，无需对抑郁症患者进行无差别甲状腺检查。鉴于抗甲状腺抗体的结果以及抑郁症人群中患病率的研究较少，似乎有必要进行更大样本的研究和对先前研究的荟萃分析。
