[非肽脾脏因子影响下的免疫系统反应]
[The reactions of the immune system under the influence of a nonpeptide splenic factor].
作者信息
Tron'ko M D, Bynkova L M, Boĭko M H, Synel'nukova H L, Oliĭnyk B V
机构信息
V. P. Komissarenko Institute of Endocrinology and Metabolism, Academy of Medical Sciences of Ukraine, Kiev.
出版信息
Fiziol Zh (1994). 2000;46(4):3-7.
The influence of low-molecular nonpeptide preparation splenosid obtained from bovine spleen on the cytotoxic activity of natural killers, reaction of complement binding and the immune responsibility was investigated. It was shown that even single treatment of rats with splenosid in a dose of 300 mkg/100 g in 48 hours stimulates the cytolytic activity of splenocytes on target cells (sheep erythrocytes). The same results were obtained in vitro. The treatment of guinea pigs with splenosid reduces the complement activity in serum. This preparation depresses the splenocyte immunoreactivity in sensibilized mice in a dose-dependent manner. The data obtained complete our knowledges about biological activity of splenosid.
研究了从牛脾脏获得的低分子非肽制剂脾核苷对自然杀伤细胞的细胞毒性活性、补体结合反应和免疫应答的影响。结果表明，即使以300微克/100克的剂量对大鼠单次注射脾核苷，48小时后也能刺激脾细胞对靶细胞（绵羊红细胞）的溶细胞活性。体外实验也得到了相同的结果。用脾核苷处理豚鼠可降低血清中的补体活性。该制剂以剂量依赖的方式抑制致敏小鼠的脾细胞免疫反应性。所获得的数据完善了我们对脾核苷生物活性的认识。
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