Grant S A, Bettencourt K, Krulevitch P, Hamilton J, Glass R
Center for Biomedical Engineering, Michigan Technological University, Houghton, USA.
Crit Rev Biomed Eng. 2000;28(1-2):159-63. doi: 10.1615/critrevbiomedeng.v28.i12.270.
This article describes fiber optic and electrochemical pH sensors that could become part of a therapeutic arsenal to quickly and aggressively treat stroke victims as well as people who have suffered brain trauma. The fiber optic sensor design was based on the immobilization of a pH-sensitive dye, seminaphthorhodamine-1 carboxylate (SNARF-1C), onto the end of a 125-microm-diameter silica optical fiber using the sol-gel method. A miniature bench-top fluorimeter system was developed for use with the optical fiber to obtain pH measurements. The electrochemical sensor was based on sputter-coated iridium oxide thin films. Linear and reproducible responses for both sensors were obtained in human blood with pH varying between 6.8 ato 8.0, which encompasses the clinically relevant range. In vivo studies were also performed and results indicated that both types of sensors tracked pH with very little drift.
本文介绍了光纤和电化学pH传感器，它们有望成为治疗武器库的一部分，用于快速、积极地治疗中风患者以及脑外伤患者。光纤传感器的设计是基于使用溶胶-凝胶法将pH敏感染料半萘罗丹明-1羧酸盐（SNARF-1C）固定在直径为125微米的二氧化硅光纤末端。开发了一种微型台式荧光计系统，用于与光纤配合以获得pH测量值。电化学传感器基于溅射涂覆的氧化铱薄膜。在pH值在6.8至8.0之间变化的人体血液中，两种传感器都获得了线性且可重复的响应，该范围涵盖了临床相关范围。还进行了体内研究，结果表明两种类型的传感器跟踪pH值时漂移很小。
