Mohapel P, Hannesson D K, Armitage L L, Gillespie G W, Corcoran M E
Department of Psychology, University of Saskatchewan, Saskatoon, Canada.
Epilepsia. 2000 Sep;41(9):1095-101. doi: 10.1111/j.1528-1157.2000.tb00313.x.
Lesions of the claustrum in cats and primates have been shown to disrupt the development and expression of amygdaloid-kindled seizures in cats and primates. Because the structure and connectivity of the claustrum can vary between species, we wanted to examine the effects of claustral lesions on kindling in rats.
One group of rats received bilateral radiofrequency lesions of both anterior and posterior regions of the claustrum before amygdaloid kindling. Another group of rats received bilateral anterior and posterior radiofrequency lesions of the claustrum after amygdaloid kindling. Some rats were tested for transfer of kindling to the contralateral amygdala after claustral lesions.
Small lesions that destroyed 13% of the claustrum were capable of delaying, but not blocking, amygdaloid kindling. The delay in kindling was due to an increase in the stimulation trials required to kindle to stage 5 seizures. The lesions had no effect on established kindled seizures or on transfer to the contralateral amygdala.
As in other species, the claustrum in the rat appears to play a role in kindling from the amygdala. Because of the restricted size of our claustral lesions, however, we were unable to conclusively assess the full extent of the claustrum's participation in limbic kindling.
已表明猫和灵长类动物的屏状核损伤会破坏猫和灵长类动物杏仁核点燃性癫痫发作的发展和表达。由于屏状核的结构和连接性在不同物种之间可能有所不同，我们想研究屏状核损伤对大鼠点燃的影响。
一组大鼠在杏仁核点燃前接受双侧屏状核前后区域的射频损伤。另一组大鼠在杏仁核点燃后接受双侧屏状核前后射频损伤。一些大鼠在屏状核损伤后测试点燃向对侧杏仁核的转移情况。
破坏13%屏状核的小损伤能够延迟但不能阻断杏仁核点燃。点燃延迟是由于点燃至5期癫痫发作所需的刺激试验增加。这些损伤对已确立的点燃性癫痫发作或向对侧杏仁核的转移没有影响。
与其他物种一样，大鼠的屏状核似乎在杏仁核点燃中起作用。然而，由于我们的屏状核损伤范围有限，我们无法最终评估屏状核参与边缘系统点燃的全部程度。
