Maderazo E G, Quintiliani R, Tilton R C, Bartlett R, Joyce N C, Andriole V T
Antimicrob Agents Chemother. 1975 Jul;8(1):54-7. doi: 10.1128/AAC.8.1.54.
The activity of minocycline and tetracycline against 23 isolates of Acinetobacter calcoaceticus var. anitratus (syn. Herellea vaginicola) and 178 strains of Serratia marcescens was determined by disk and microdilution methods. The results indicate that minocycline is highly active against this species of Acinetobacter, all but one strain being inhibited by 0.007 mug of the antibiotic per ml. Tetracycline was also active, though to a lesser degree, against A. calcoaceticus. Of the 178 strains of S. marcescens tested, only seven (3.9%) had a minimum inhibitory concentration of 2 mug or less of minocycline per ml. Tetracycline was less active than minocycline against S. marcescens; with 2 mug of tetracycline per ml, only 2 of 152 (1.3%) strains were inhibited. At concentrations of 8 and 16 mug of minocycline per ml, which can be achieved in the urine with the usual doses, 44.9 and 63.5% of S. marcescens strains were inhibited, which implies its possible usefulness for the therapy of urinary tract infection due to this organism.
采用纸片法和微量稀释法测定了米诺环素和四环素对23株醋酸钙不动杆菌硝酸盐阴性变种（同阴道哈夫尼亚菌）及178株粘质沙雷菌的活性。结果表明，米诺环素对该种不动杆菌具有高度活性，除1株外，所有菌株均被每毫升0.007微克的抗生素所抑制。四环素对醋酸钙不动杆菌也有活性，不过活性程度较低。在检测的178株粘质沙雷菌中，只有7株（3.9%）每毫升米诺环素的最低抑菌浓度为2微克或更低。四环素对粘质沙雷菌的活性低于米诺环素；每毫升2微克四环素时，152株中只有2株（1.3%）被抑制。每毫升8微克和16微克的米诺环素浓度在常规剂量下可在尿液中达到，此时分别有44.9%和63.5%的粘质沙雷菌菌株被抑制，这表明它可能对治疗由该菌引起的尿路感染有用。
