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米诺环素的体外抗菌活性及其药敏试验中所用琼脂培养基的影响。

In vitro antibacterial activity of minocycline and effect of agar medium utilized in its susceptibility testing.

作者信息

Washington J A, Yu P K, Martin W J

出版信息

Appl Microbiol. 1970 Feb;19(2):259-63. doi: 10.1128/am.19.2.259-263.1970.

DOI:10.1128/am.19.2.259-263.1970
PMID:4392357
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC376662/
Abstract

The in vitro activity of minocycline against 1,028 bacterial strains was determined in parallel in Mueller Hinton Agar and Trypticase Soy Agar. The broad antibacterial effect of minocycline against gram-positive cocci and gram-negative bacilli is confirmed. Minimal inhibitory concentrations for gram-positive bacteria in Mueller Hinton Agar were at least twofold less than in Trypticase Soy Agar. Minimal inhibitory concentrations for gram-negative bacilli in Mueller Hinton Agar were usually fourfold less than in Trypticase Soy Agar.

摘要

在穆勒-欣顿琼脂和胰蛋白胨大豆琼脂中同时测定了米诺环素对1028株细菌的体外活性。证实了米诺环素对革兰氏阳性球菌和革兰氏阴性杆菌具有广泛的抗菌作用。在穆勒-欣顿琼脂中革兰氏阳性菌的最低抑菌浓度比在胰蛋白胨大豆琼脂中至少低两倍。在穆勒-欣顿琼脂中革兰氏阴性杆菌的最低抑菌浓度通常比在胰蛋白胨大豆琼脂中低四倍。

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In vitro antibacterial activity of minocycline and effect of agar medium utilized in its susceptibility testing.米诺环素的体外抗菌活性及其药敏试验中所用琼脂培养基的影响。
Appl Microbiol. 1970 Feb;19(2):259-63. doi: 10.1128/am.19.2.259-263.1970.
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本文引用的文献

1
The use of a bile-aesculin medium and of Maxted's technique of Lancefield grouping in the identification of enterococci (group D streptococci).在肠球菌（D群链球菌）鉴定中使用胆汁七叶苷培养基及马克斯泰德氏兰斯菲尔德分组技术。
J Clin Pathol. 1954 May;7(2):160-3. doi: 10.1136/jcp.7.2.160.
2
In vitro activity of minocycline, a new tetracycline.
Am J Med Sci. 1968 Apr;255:252-8. doi: 10.1097/00000441-196804000-00006.
3
Susceptibility of common pathogenic bacteria to seven tetracycline antibiotics in vitro.常见病原菌对七种四环素类抗生素的体外敏感性
Am J Med Sci. 1968 Mar;255:179-95. doi: 10.1097/00000441-196803000-00005.
4
Antibiotic activity in the presence of agar.琼脂存在时的抗生素活性。
Appl Microbiol. 1967 Jan;15(1):31-4. doi: 10.1128/am.15.1.31-34.1967.