Montgomerie J Z, Pickett M J, Yoshimori R N, Chow A W, Guze L B
Antimicrob Agents Chemother. 1976 Jul;10(1):102-5. doi: 10.1128/AAC.10.1.102.
The in vitro activity of minocycline against Acinetobacter calcoaceticus var. anitratus (Herellea vaginicola) was examined. All strains of A. anitratus were inhibited by minocycline at concentrations of 0.4 mug/ml or less. The strains studied were considerably more susceptible to minocycline than tetracycline. No difference between the susceptibility to minocycline and tetracycline was seen with Escherichia coli, Klebsiella pneumoniae, Enterobacter and Proteus sp. A regression line of the log minimal inhibitory concentration (MIC) values and the diameter of the zone of inhibition, determined by the Kirby-Bauer technique, showed good linear correlation for minocycline. Comparison of the disk diffusion results and MICs indicated that an inhibitory zone size of 19 mm produced by a 30-mug minocycline disk was equivalent to a MIC of 3.1 mug/ml, a serum concentration achieved by oral administration of the drug. When the zone of inhibition was greater than 19 mm, however, there was poor correlation with the MIC for Enterobacteriaceae.
对米诺环素针对醋酸钙不动杆菌硝酸盐阴性变种（阴道哈夫尼亚菌）的体外活性进行了检测。所有硝酸盐阴性不动杆菌菌株在浓度为0.4μg/ml或更低时均被米诺环素抑制。所研究的菌株对米诺环素的敏感性明显高于四环素。在大肠杆菌、肺炎克雷伯菌、肠杆菌和变形杆菌属中，未观察到对米诺环素和四环素敏感性的差异。通过Kirby-Bauer技术测定的对数最小抑菌浓度（MIC）值与抑菌圈直径的回归线显示米诺环素具有良好的线性相关性。纸片扩散结果与MIC的比较表明，30μg米诺环素纸片产生的19mm抑菌圈大小相当于3.1μg/ml的MIC，这是口服该药物后可达到的血清浓度。然而，当抑菌圈大于19mm时，与肠杆菌科的MIC相关性较差。
