抗菌剂对嗜肺军团菌的体外活性。
In vitro activity of antimicrobial agents on Legionnaires disease bacterium.
作者信息
Thornsberry C, Baker C N, Kirven L A
出版信息
Antimicrob Agents Chemother. 1978 Jan;13(1):78-80. doi: 10.1128/AAC.13.1.78.
Six isolates of Legionnaires disease bacteria were tested for their susceptibility to 22 antimicrobial agents. The most active agent was rifampin (minimal inhibitory concentration, </=0.01 mug/ml). On the basis of minimal inhibitory concentration breakpoints that have been used to categorize susceptibility for most of these drugs, the organisms were susceptible to rifampin, cefoxitin, erythromycin, the aminoglycosides, minocycline and doxycycline, chloramphenicol, ampicillin, penicillin G, carbenicillin, colistin, and sulfamethoxazole-trimethoprim (19:1 ratio); sensitive to intermediate in susceptibility to tetracycline, methicillin, cefamandole, cephalothin, and clindamycin; and resistant to vancomycin. More clinical data must be obtained before an optimal therapeutic regimen can be recommended.
对六株军团病杆菌分离株进行了22种抗菌剂的药敏试验。最有效的药物是利福平（最低抑菌浓度，≤0.01μg/ml）。根据已用于对大多数这些药物的敏感性进行分类的最低抑菌浓度断点，这些菌株对利福平、头孢西丁、红霉素、氨基糖苷类、米诺环素和多西环素、氯霉素、氨苄西林、青霉素G、羧苄西林、黏菌素以及磺胺甲恶唑-甲氧苄啶（19:1比例）敏感；对四环素、甲氧西林、头孢孟多、头孢噻吩和克林霉素的敏感性为中介；对万古霉素耐药。在推荐最佳治疗方案之前，必须获得更多临床数据。
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