Damle S V, Patil P N, Salunkhe M M
Department of Chemistry, The Institute of Science, Mumbai, India.
Bioorg Med Chem. 2000 Aug;8(8):2067-70. doi: 10.1016/s0968-0896(00)00131-0.
(+/-)-Atenolol/(+/-)-propranolol and their acetates were incubated with the fungus Rhizopus arrhizus and Geotrichum candidum separately for different time intervals to afford (S)-atenolol/(S)-propranolol in good optical yield. The time and pH for this biotransformation was optimised. The present biodegradations using Rhizopus arrhizus and Geotrichum candidum provides a simple and useful method to obtain (S)-atenolol and (S)-propranolol which are active enantiomers of the beta-adrenergic blockers.
