Lozzio B B
Biomedicine. 1976 Jun;24(3):144-7.
A new animal model characterized by hereditary athymia and asplenia was developed by breeding congenitally athymic with hereditarily asplenic mice. The new hybrids have no cellular immunity and produce significantly less antibody than nude mice. The lasat mouse has been found useful for the transplantation of normal and malignant hemopoietic cells and other neoplastic tissues of human origin.
通过将先天性无胸腺小鼠与遗传性无脾小鼠杂交,培育出了一种以遗传性无胸腺和无脾为特征的新动物模型。这种新的杂交种没有细胞免疫,产生的抗体也比裸鼠少得多。已发现最后一种小鼠可用于移植正常和恶性造血细胞以及其他人类来源的肿瘤组织。