遗传性无脾无胸腺小鼠：人骨髓性白血病细胞的移植
Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells.
作者信息
Lozzio B B, Machado E A, Lozzio C B, Lair S
出版信息
J Exp Med. 1976 Jan 1;143(1):225-31. doi: 10.1084/jem.143.1.225.
Abstract
A new animal model characterized by hereditary athymia and asplenia was used as a recipient of chronic myelogenous leukemic (CML) cells with the Philadelphia (Ph1+) chromosome. Transplanted CML cells form solid vascularized tumors containing cells similar to those seen in the patient in a long-term culture. Cells taken from the tumors were nearly triploid, retained all human chromosome markers, and had the same antigenic determinants(s) as cells in culture.
摘要
一种以遗传性无胸腺和无脾为特征的新动物模型被用作带有费城（Ph1+）染色体的慢性粒细胞白血病（CML）细胞的受体。移植的CML细胞形成了含有与长期培养的患者体内所见细胞相似的细胞的实体血管化肿瘤。从肿瘤中获取的细胞几乎是三倍体，保留了所有人类染色体标记，并且具有与培养细胞相同的抗原决定簇。
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