Maclean C J, Baker H F, Ridley R M, Mori H
MRC Comparative Cognition Team, Department of Experimental Psychology, Cambridge, United Kingdom.
J Neural Transm (Vienna). 2000;107(7):799-814. doi: 10.1007/s007020070060.
Cerebral beta-amyloid occurs in elderly animals of some species and in Alzheimer's disease. Previously, we injected 3 young marmosets intracerebrally with brain tissue from a patient with Alzheimer's disease. Six years later, when the monkeys were middle aged, we found moderate numbers of intracerebral plaques and cerebrovascular deposits containing beta-amyloid. We have re-examined these brains and those of 10 other marmosets injected with brain homogenate containing beta-amyloid, and have found some beta-amyloid in animals injected more than 4 years previously. We have found beta-amyloid in 4 of 26 elderly control marmosets, but not in 9 young to middle-aged control marmosets. The beta-amyloid found in middle aged marmosets injected with Alzheimer brain tissue was, therefore, not a consequence of their age. Deposits in large cerebral vessels in elderly marmosets, and in marmosets previously injected with brain tissue containing beta-amyloid, reacted with antibodies to Abeta and Abeta1-40; plaques and microvessel deposits reacted with antibodies to Abeta and Abeta1-42.
大脑β-淀粉样蛋白出现在某些物种的老年动物以及阿尔茨海默病患者中。此前，我们向3只幼年狨猴脑内注射了来自一名阿尔茨海默病患者的脑组织。6年后，当这些猴子步入中年时，我们发现脑内有适量的含有β-淀粉样蛋白的斑块和脑血管沉积物。我们重新检查了这些大脑以及另外10只注射了含β-淀粉样蛋白脑匀浆的狨猴的大脑，发现在4年多前注射过的动物体内有一些β-淀粉样蛋白。我们在26只老年对照狨猴中的4只身上发现了β-淀粉样蛋白，但在9只幼年到中年的对照狨猴中未发现。因此，向注射了阿尔茨海默病脑组织的中年狨猴体内发现的β-淀粉样蛋白并非其年龄所致。老年狨猴大脑大血管中的沉积物，以及之前注射过含β-淀粉样蛋白脑组织的狨猴体内的沉积物，与抗Aβ和Aβ1-40抗体发生反应；斑块和微血管沉积物与抗Aβ和Aβ1-42抗体发生反应。
