Baker H F, Ridley R M, Duchen L W, Crow T J, Bruton C J
Division of Psychiatry, Clinical Research Centre, Harrow, United Kingdom.
Ann N Y Acad Sci. 1993 Sep 24;695:228-31. doi: 10.1111/j.1749-6632.1993.tb23057.x.
Moderate numbers of amyloid plaques with associated argyrophilic dystrophic neurites and cerebral amyloid angiopathy (CAA) but no neurofibrillary tangles (NFTs) were found in the brains of 3 middle-aged common marmosets (Callithrix jacchus) inoculated intracerebrally (i.c.) 6-7 years earlier with brain tissue from a patient with early onset Alzheimer's disease. The plaques and vascular amyloid stained positively with antibodies to beta (A4)-protein. The brains of 3 age-matched control marmosets from the same colony did not show these neuropathological features. beta-amyloid plaques and CAA (but no spongiform encephalopathy) were also found in the brain of a marmoset inoculated with brain tissue from a patient with prion disease with concomitant beta-amyloid plaques and CAA. An occasional beta-amyloid plaque was found in the brains of two marmosets inoculated with brain tissue from elderly patients. No beta-amyloid plaques nor CAA were found in 6 other marmosets who were older than the inoculated marmosets, 10 further marmosets who were slightly younger but who had been inoculated several years previously with brain tissue which did not contain beta-amyloid, and 10 younger marmosets who had been subjected to various neurosurgical procedures. These results suggest that beta-amyloidosis is a transmissible process.
在3只6 - 7年前经脑内（i.c.）接种早发型阿尔茨海默病患者脑组织的中年普通狨猴（Callithrix jacchus）大脑中，发现有中等数量的淀粉样斑块，伴有嗜银性营养不良性神经突和脑淀粉样血管病（CAA），但未发现神经原纤维缠结（NFTs）。这些斑块和血管淀粉样物质用β（A4）蛋白抗体染色呈阳性。来自同一群体的3只年龄匹配的对照狨猴大脑未显示出这些神经病理学特征。在一只接种了伴有β淀粉样斑块和CAA的朊病毒病患者脑组织的狨猴大脑中，也发现了β淀粉样斑块和CAA（但无海绵状脑病）。在两只接种老年患者脑组织的狨猴大脑中偶尔发现有β淀粉样斑块。在另外6只比接种狨猴年龄大的狨猴、10只年龄稍小但几年前接种过不含β淀粉样物质脑组织的狨猴以及10只接受过各种神经外科手术的年轻狨猴大脑中，均未发现β淀粉样斑块和CAA。这些结果表明β淀粉样变性是一个可传播的过程。
