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粗糙脉孢菌am基因与NADP特异性谷氨酸脱氢酶:突变序列变化及功能影响——更多突变体及总结

The Neurospora am gene and NADP-specific glutamate dehydrogenase: mutational sequence changes and functional effects--more mutants and a summary.

作者信息

Fincham J R, Kinsey J A, Fuentes A M, Cummings N J, Connerton I F

机构信息

Institute of Cell and Molecular Biology, University of Edinburgh, UK.

出版信息

Genet Res. 2000 Aug;76(1):1-10. doi: 10.1017/s0016672300004602.

DOI:10.1017/s0016672300004602
PMID:11006629
Abstract

A further series of mutant am alleles, encoding potentially active NADP-specific glutamate dehydrogenase (GDH) and capable of complementation in heterocaryons, have been characterized with respect to both GDH properties and DNA sequence changes. Several mutants previously studied, and some of their same-site or second-site revertants, have also been sequenced for the first time. We present a summary of what is known of the properties of all am mutants that have been defined at the sequence level.

摘要

另一系列编码潜在活性NADP特异性谷氨酸脱氢酶(GDH)且能够在异核体中互补的突变型am等位基因,已在GDH特性和DNA序列变化方面进行了表征。几个先前研究过的突变体及其一些同一位点或第二位点的回复突变体也首次进行了测序。我们总结了在序列水平上已定义的所有am突变体的已知特性。

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