Mitsuhashi O, Schucher R, Kalant N
J Lab Clin Med. 1975 Oct;86(4):683-9.
A constant infusion isotope dilution procedure for measurement of plasma insulin flux rates was performed in acutely eviscerated dogs receiving an infusion of nonlabeled insulin; the calculated rate of insulin flux corresponded closely to that of the administered rate, thus validating the isotope dilution procedure. Flux rates of insulin and glucose were measured simultaneously at different steady levels in intact dogs. There was a linear relationship between plasma insulin concentration and insulin flux rate. In each animal there was also a linear relationship between glucose flux rate and insulin concentration, and between rates of glucose flux and insulin flux, but there was considerable inter-animal variation in the slope of the regression lines.
在接受未标记胰岛素输注的急性去内脏犬中，采用恒定输注同位素稀释法测量血浆胰岛素通量率；计算出的胰岛素通量率与给药率密切对应，从而验证了同位素稀释法。在完整犬中，在不同稳定水平下同时测量胰岛素和葡萄糖的通量率。血浆胰岛素浓度与胰岛素通量率之间存在线性关系。在每只动物中，葡萄糖通量率与胰岛素浓度之间、葡萄糖通量率与胰岛素通量率之间也存在线性关系，但回归线斜率在动物间存在相当大的差异。
