葡萄糖与蔗糖作为失血性休克中稀释容量测定指标的比较。

Comparison of glucose and sucrose as an indicator for dilution volumetry in haemorrhagic shock.

作者信息

Shimodate Y, Koh H, Ishihara H, Matsuki A

机构信息

Department of Anesthesiology, University of Hirosaki School of Medicine, Japan.

出版信息

Eur J Anaesthesiol. 1995 Jul;12(4):397-401.

PMID:7588669

Abstract

A new technique for dilution volumetry using glucose as an indicator is proposed. The initial distribution volume of glucose (Vdgluc) was calculated in 11 adult mongrel dogs using a one-compartment model, and Vdgluc was then compared with the initial distribution volume of sucrose (Vdsucr), which is less metabolized. Insulin concentrations in the plasma were measured to calculate the insulinogenic index. The Vdgluc and the Vdsucr at baseline and after induced haemorrhagic shock (30 mL kg-1) were calculated. There was a significant correlation (r = 0.84, n = 22, P < 0.001) between Vdgluc and Vdsucr, but not between Vdgluc and the insulinogenic index. The limits of agreement ( +/- 2SD) between the two methods were +0.32 to -0.08L. Vdgluc indicates the volume of the central compartment, but cannot replace Vdsucr for clinical purposes. Glucose can be used repeatedly as an indicator for easy and safe dilution volumetry in vivo.

摘要

提出了一种以葡萄糖为指示剂的稀释体积测量新技术。使用单室模型计算了11只成年杂种犬的葡萄糖初始分布容积（Vdgluc），然后将Vdgluc与代谢较少的蔗糖初始分布容积（Vdsucr）进行比较。测量血浆中的胰岛素浓度以计算胰岛素生成指数。计算了基线时以及诱导失血性休克（30 mL/kg）后的Vdgluc和Vdsucr。Vdgluc与Vdsucr之间存在显著相关性（r = 0.84，n = 22，P < 0.001），但Vdgluc与胰岛素生成指数之间无相关性。两种方法之间的一致性界限（±2SD）为+0.32至 -0.08L。Vdgluc表示中央室的容积，但在临床应用中不能替代Vdsucr。葡萄糖可反复用作指示剂，便于在体内进行安全的稀释体积测量。