de Mendonça A, Sebastião A M, Ribeiro J A
Laboratory of Neurosciences, Faculty of Medicine of Lisbon, Av. Professor Egas Moniz, 1649-035, Lisbon, Portugal.
Brain Res Brain Res Rev. 2000 Sep;33(2-3):258-74. doi: 10.1016/s0165-0173(00)00033-3.
A neuroprotective role for adenosine is commonly assumed. Recent studies revealed that adenosine may unexpectedly, under certain circumstances, have the opposite effects contributing to neuronal damage and death. The basis for this duality may be the activation of distinct subtypes of adenosine receptors, interactions between these receptors, differential actions on neuronal and glial cells, and various time frames of adenosinergic compounds administration. If these aspects are understood, adenosine should remain an interesting target for therapeutical neuroprotective approaches after all.
人们普遍认为腺苷具有神经保护作用。最近的研究表明，在某些情况下，腺苷可能出人意料地产生相反的效果，导致神经元损伤和死亡。这种双重性的基础可能是腺苷受体不同亚型的激活、这些受体之间的相互作用、对神经元和胶质细胞的不同作用以及腺苷能化合物给药的不同时间框架。如果理解了这些方面，腺苷终究仍应是治疗性神经保护方法的一个有趣靶点。
