Fredholm B B
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Int Rev Neurobiol. 1997;40:259-80.
In summary, there is good evidence that adenosine is an endogenous neuroprotective agent. Probably several mechanisms can contribute to this effect and the relative importance of these mechanisms may depend on the type of ischaemia. There is also evidence that drugs that affect adenosine may be used therapeutically. An important caveat is that acute and long-term effects of adenosine receptor agonists and antagonists differ widely. This effect inversion suggests that drugs that affect adenosine receptors also induce important adaptive events in the central nervous system. Such adaptive effects may also be evident in the case of other agents, which emphasizes that the long-term usefulness of a therapeutic strategy cannot always be judged only from acute studies.
总之，有充分证据表明腺苷是一种内源性神经保护剂。可能有多种机制促成这种效应，且这些机制的相对重要性可能取决于缺血的类型。也有证据表明，影响腺苷的药物可用于治疗。一个重要的告诫是，腺苷受体激动剂和拮抗剂的急性和长期效应差异很大。这种效应反转表明，影响腺苷受体的药物也会在中枢神经系统中引发重要的适应性事件。在其他药物的情况下，这种适应性效应也可能很明显，这强调了治疗策略的长期有效性不能总是仅根据急性研究来判断。
