Wassner S J, Sanders R, Orloff S, Sheldon G F, Holliday M A
Am J Clin Nutr. 1979 Jul;32(7):1497-504. doi: 10.1093/ajcn/32.7.1497.
Six malnourished patients were studied during intravenous nutrition therapy to compare the efficiency of essential and general amino acids when given as the sole nitrogen source during intravenous nitrogen therapy. A cross-over design was used so that each patient received both essential amino acids plus arginine and histidine and a general amino acid solution in random order. Glucose provided the remainder of the energy and both infusions contained 2 g of amino acid per 100 kcal. Each patient's daily urea nitrogen production was greater during infusion of the general amino acid solution. Consequently, nitrogen intake minus urea nitrogen production was significantly greater when the essential amino acid solution was infused. Plasma amino acid levels were determined on each patient during both essential and general amino acid infusion. Abnormalities tend to reflect the composition of the amino acid solutions as well as their administration directly into the systemic circulation bypassing the portal circulation.
对6名营养不良患者进行了静脉营养治疗研究，以比较在静脉氮治疗期间将必需氨基酸和普通氨基酸作为唯一氮源时的效率。采用交叉设计，使每位患者以随机顺序接受必需氨基酸加精氨酸和组氨酸以及普通氨基酸溶液。葡萄糖提供其余能量，两种输注液每100千卡含2克氨基酸。在输注普通氨基酸溶液期间，每位患者的每日尿素氮生成量更大。因此，输注必需氨基酸溶液时，氮摄入量减去尿素氮生成量显著更高。在输注必需氨基酸和普通氨基酸期间，对每位患者测定了血浆氨基酸水平。异常情况往往反映了氨基酸溶液的组成以及它们直接注入体循环而绕过门静脉循环的情况。
